I use Vista Home Premium at home. I support XP Pro and Server 2003 at work and I doubt we'll ever go to Vista (or office 2007 for that matter).
I have to say I've had a very good experience with Vista at home. I use my home computer mostly for digital photography, downloading music and making CD's, Office 2003, Internet, and I use my Vista pc as a music server for my MP3 network appliances. It is fine for all of these functions. I definitely had 'driver' issues in the beginning (I bought it and installed it the day Vista was released). I knew full well that drivers would be an issue, just like when I upgraded to XP. I'm not a gamer, so I have not had the slowness problems the gamers are experiencing with Vista.
At work XP Pro seems to work just fine and is very reliable and easy to support. We went through several upgrades (95, then NT Workstation, then 2000, now XP pro). Nobody wants to go through another upgrade unless there is a very good reason to do so.