Attached is a data set (#1) containing time to onset of angina at baseline (hour 0) and at 2, 7 and 12 hours post baseline for three patients in each of three dose groups (0 bid, 4 mg bid and 6 mg bid) in each of two centers.
A.Provide descriptive statistics (n, mean, st. dev) by dose group and time of stress test for each center and across centers combined.
B.Provide 95% CIs and p-values for the three pairwise comparisons among dose groups for the change in time to angina onset from hour 0 to hour 12 (CH_TAO_b_12):
1.Using a linear model where CH_TAO_b_12 is the response variable and explanatory factors are: Center and (dose) Group
2.Using a linear model where CH_TAO_b_12 is the response variable and explanatory factors are: time-to-anginal onset at hour 0, Center and (dose) Group
3.Test whether there are center differences
4.Test whether there is a significant treatment-by-center interaction
NOTE. For IV turn in, the SAS program, SAS log and SAS output.
DATA SET 1: Time to Anginal Onset
Group PAT # Center Hour 0 Hour 2 Hour 7 Hour 12
0 mg bid 10115.15.35.86.1
0 mg bid 10216.15.46.57.1
0 mg bid 10315.86.27.06.5
4 mg bid 10416.28.58.17.1
4 mg bid 10515.48.47.76.1
4 mg bid 10616.26.86.95.9
6 mg bid 10714.88.17.65.2
6 mg bid 108 1 5.1 7.6 7.1 6.1
6 mg bid 10915.98.57.26.8
0 mg bid 20125.16.56.26.4
0 mg bid 20226.15.86.16.9
0 mg bid 20324.85.65.26.2
4 mg bid 20425.07.67.16.1
4 mg bid 20524.48.27.66.4
4 mg bid 20625.46.15.65.7
6 mg bid 20725.68.27.87.1
6 mg bid 20824.87.86.25.1
6 mg bid 20926.07.07.16.4
A.Provide descriptive statistics (n, mean, st. dev) by dose group and time of stress test for each center and across centers combined.
B.Provide 95% CIs and p-values for the three pairwise comparisons among dose groups for the change in time to angina onset from hour 0 to hour 12 (CH_TAO_b_12):
1.Using a linear model where CH_TAO_b_12 is the response variable and explanatory factors are: Center and (dose) Group
2.Using a linear model where CH_TAO_b_12 is the response variable and explanatory factors are: time-to-anginal onset at hour 0, Center and (dose) Group
3.Test whether there are center differences
4.Test whether there is a significant treatment-by-center interaction
NOTE. For IV turn in, the SAS program, SAS log and SAS output.
DATA SET 1: Time to Anginal Onset
Group PAT # Center Hour 0 Hour 2 Hour 7 Hour 12
0 mg bid 10115.15.35.86.1
0 mg bid 10216.15.46.57.1
0 mg bid 10315.86.27.06.5
4 mg bid 10416.28.58.17.1
4 mg bid 10515.48.47.76.1
4 mg bid 10616.26.86.95.9
6 mg bid 10714.88.17.65.2
6 mg bid 108 1 5.1 7.6 7.1 6.1
6 mg bid 10915.98.57.26.8
0 mg bid 20125.16.56.26.4
0 mg bid 20226.15.86.16.9
0 mg bid 20324.85.65.26.2
4 mg bid 20425.07.67.16.1
4 mg bid 20524.48.27.66.4
4 mg bid 20625.46.15.65.7
6 mg bid 20725.68.27.87.1
6 mg bid 20824.87.86.25.1
6 mg bid 20926.07.07.16.4