You already have the funny answers. The serious answer is quantum physics. We can already see, with electron microscopes, individual atoms. From the way that atoms, electrons, and sub-atomic particles behave, we can be sure that only so much information can be packed into one atom. It's just a few 1000 bits (about the amount of information in a few dozen words.) That amount of information is way way too small for any thing at that level to be alive, much less have a civilization.