Actually my local multiplex plays way more films that are only on about 20 screens nationwide. But with these limited release films at the multiplex, I find myself being one of about 5 people in the screen, sometimes less. It's got nothing to do with the type of cinema and everything to do with the film. I'll be watching The Fountain by myself while nextdoor Epic Movie will be playing to the chavs.
The local arthouse ones like to play the same film for a whole month even though it's on general release everywhere anyway, just because it's critically acclaimed.
For actual foreign arthouse films I have to go to the NFT, which is handy for me being in London, but sucks for everyone else.