The Simpsons. That did very well for itself. Plus, I would tend to say Aqua Teen Hunger Force, but Warners pretty much gave it a limited release. Of course, I live in the you know where where the you know what went down, so It could have been nationally released differently out of state.
But the teens would rather go for the mindless blood porn slaughter films like Saw. I mean, LOTR, Spidey, and that stuff does amazingly with those. But the mainstream wants crappy, cheaply made gorefests (no jokes about An Inconvieniant Truth please). At least that's what I get from observation.
I have no doubt if they made a crappy parody film called "Animated Movie", it would do undeservedly well though. Which would suck big time, since I've had an idea like that for some time now.