Total Drama Island is fairly well known to people who've seen it on Teletoon or on Cartoon Network, but TDI's popularity still has quite a way to go before it comes close to being equal to that of Scooby Doo, The Muppet Show, Ren & Stimpy, DBZ or Pok?mon. Not enough adults watch TDI for it to be parodied/referenced on a show like The Simpsons or King of the Hill.
Besides, how does one parody a show that is itself a parody?