Since I have a reputation to uphold, I'm going to go slightly more obscure

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Cadillacs and Dinosaurs: The original
Xenozoic Tales comics were wicked cool (and still unfinished). At its best, the original cartoon in the 1980's didn't dumb things down too badly. Still, the lame animation didn't compare to Mark Schultz's original beautiful artwork and at its worst, it was another really rotten toon from the '80's. I'd like for someone to take a more serious crack at this one. It's babes and beefcake driving classic 50's automobiles and fighting dinosaurs. What's not to like?
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Dungeons and Dragons: I don't know if I'd want to see a faithful adaptation of the Forgotten Realms stuff, but getting more fantasy animation on the air can't be a bad thing. Might also wash out the sour taste left behind by that execrable
Dragonlance animated DTV.
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The Legend of Calamity Jane: I actually don't want a remake of this as much as I want someone to air the whole series and then make more, or put it on DVD or iTunes. Only watched a bit of one episode, but the visual style knocked me out and the story didn't seem bad. Plus, more Westerns, please. And along those lines...
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The Lone Ranger: Way back when I was a kid, Filmation made a Tarzan/Lone Ranger/Zorro adventure hour. Of the 3, I'd say I want to see a really good adaptation of the Lone Ranger again, though I wouldn't say no to a good Tarzan or Zorro adaptation, either. Mostly, the Lone Ranger's got cowboy hats, silver bullets, and a certain Nobility of Spirit -- again, what's not to like?
In general, though, I'd prefer to see something new rather than a remake of something I've already seen.