I think Alice Hoffman's The Probable Future would make a great film if they stick to the book. Even though I dont really like Catherine Zeta-Jones that much, I could see her as Jenny.
I would also like to see any of Barbara Kingsolver's books as a movie, especially The Bean Trees, Pigs In Heaven, Animal Dreams & The Poisonwood Bible (I think Charlize Therron would be great in that one)