The options for BlockInput are simple. You select which hotkey you want to use to activate the program and how many seconds you want to the application to lock the input from your mouse and keyboard. The default is CTRL+Q and 5 seconds, presumably so the first time you test the program you don't find yourself staring at the computer for the next half hour waiting for it to unlock. Whether you need a window of time to wipe down your mouse and keyboard with some sanitizing wipes or you have a particularly sensitive application you want to make sure isn't disturbed, BlockInput is a dead simple solution. BlockInput is freeware, Windows only. BlockInput [via gHacks]