best car audio setup? 5.25", 6.5", 6x9"?

i have a medium sized sadan and i plan to run an 18" subwoofer at the back so il have plenty of bass.But i also want to run front and rear speakers.Should i use 5.25" components in the front doors with tweeters on a-pillars or 6.5" components?

then for the rear is there a need for 6x9s as i am running a seperate woofer if not would 6.5" colxials suffice or another size altogether please dont hesitate to ask any questions

thanx for your help
 
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