With the death of syndication/Saturday Morning, I'd say leave Austin Powers alone. If they'd come up with AP:TAS back when Kid's WB was in it's glory days, or Fox Kids was still going strong, even if they syndication market was still going strong for a weekday series, then yeah, bring it on. Do the series at New Line, where The Mask TAS came from and you might have a hit.
But I can't imagine CN, Toon Disney or Nickelodean funding a show like this when they've got bigger, newer, more profitable shows to do.