one big fyi here,under no cicumsances should you take any tylenol products either right before or after you drink.that combo really hits your liver hard. i would "imagine"? one aleeve or advil before,way before you drink might be okay(tho this does hit your kidneys and some liver functions too). but hydration IS the most important thing for your body,during and after you drink. you just lose alot of fluid since alcohol acts like a diuretic. i do agre with the above poster in that drinking one drink then having a glass of water,then alcohol, might be the best way to do this. just alays make certain you have a designated driver when you are going to be drinking. planning ahead can literally save your life and the lives of other innocent people who also share the road with you. now party on. FB