About Immunotherapy

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Immunotherapy for allergies is all about helping build a your body's tolerance to an allergen and decrease your allergic response to it. The process is called desensitization.

Before beginning immunotherapy, you need to see an allergy specialist for allergy testing. They will have a multi-page questionnaire regarding your health and symptoms. You will also be instructed to refrain from some of your allergy medications for about a week prior to having your testing. The last 2 times I have arrived for testing, they have done a quick spirometry test prior to beginning the testing. (I'm not sure if this is typical for everyone or if it is because I have developed asthma over the years.)

Getting to the testing, I've had it done 3 times. Basically what they do is to introduce a small amount of the allergen into your skin to see if you have a reaction. The allergens they use are based upon your questionnaire answers and what the common allergens are for your region of the country. Once they introduce the allergen, they will have you wait a while, then they will measure the size of the reaction, or wheal. The size of the wheal (welt) helps them determine the level of severity of your allergy.

Testing type 1: They mark a grid on your back and then they do skin pricks on your back and maybe your upper arms. These are tiny pinpricks that contain the allergen. They will also do a control skin prick as well. You will lay on your stomach for 20 minutes or 1/2 hour. They may have a TV or you could listen to music or read while you wait. If you are having some reactions, it you may feel the itches pop up and become uncomfortable, but they will put some cream on it after they read your results. They will also wipe the ink off your back. They will review your results on-site after the testing and discuss your options for further treatment. My appointments were about 1 hour-1 1/2 hours depending on the wait.

Testing type 2: This is done on all areas of both of your arms. They will mark griRAB on your arms. They inject tiny amounts of the allergens into your skin. They will also do a control injection as well. They use injections of allergens in 5 different strengths for each allergen. Depending on your questionnaire, they will do a first set of injections with varying strengths. If you have allergies you know of, they will start lowest, if you don't have any known allergies, they may begin at a bit stronger strength. After the first set of injections, they wait about 15 minutes. Then they measure the wheals. If there was a strong reaction, they may or may not choose to give you the next injection of a stronger strength. If there was no reaction, they will give you an injection of a stronger strength. You will then wait another 15 minutes. They will repeat this process several times until they feel they have a good reading on the severity of your reaction for each allergen. I have some fairly severe allergies so I ended up with probably 250-300 individual injections in rows all over my arms. I'm not sure that is typical though. You will know the results as they go through the process if they talk to you about what they are doing, but they will review the results with them as they complete the process.

Once you have your results, you will discuss your follow-up treatment with your doctor or technician. If immunotherapy is recommended, they will go over their recommendations for which allergens they recommend you receive treatment for. Depending on the nuraber and severity of your allergies, you may be receiving between one and 3 injections per visit. One or two injections are more typical for most people. My personal advice is to think carefully on which treatments you accept. I have multiple allergies. I had testing a few years ago and despite multiple identified allergies, the doctor only offered immunotherapy for one of my allergens. The following-year, I went to a new allergy clinic for testing and I am now receiving treatment for 28 of my worst allergies.

Your schedule for the allergy shots will differ depending on the clinic you are visiting. When you begin the shots you will go either once or twice per week. If you are on the twice per week schedule it will probably be for about 3-6 months depending on your reaction to the shots. You will then go to once per week. They begin shots with a very small amount of your allergen. After the shots you will wait in your doctors office for 15 minutes so that you can be monitored for any severe reactions. At the end of the 15 minutes, you will have your reaction checked. They have some cream available if you are really itchy. If you have a strong reaction, they will repeat that amount each week until the reaction lessens, they will then introduce the next higher dosage. If your reaction is minimal, they will go ahead with the next higher dosage depending on your schedule. The rate at which you progress through your therapy depenRAB on your reactions. Eventually you will be able to go every other week. TowarRAB the end, you may go to once per month. When you build to the highest amount and go a while with no reactions, you will be at your maintainence dosage. You will stay at that level for the remainder of your shots. It took me about a year to hit my maintainence level.

The shot schedule typically lasts 3-5 years. My doctor predicts about 5 years with shots and 5 years off before beginning again. Some people can go in excess of 10 years between therapy sessions. It really is an individual thing.

Additional advice: Talk to your doctor about taking an antihistimine on the days of your shots if you are not on them daily. Carry Benedryl with you 'just in case'. You may also want to have some cortizone cream handy. Get a prescription for an Epi-pen and make sure you carry it with you when you are getting your shots, again 'just in case'. Ice packs make things feel better if you have a shot that gives you a large welt.

About 6 years after my first immunotherapy session, I went in for testing as my allergies had gotten worse. Testing showed that some of my allergies were severe, but some of the allergies ones that had been severe originally were only moderate this time. To me that meant that the initial immunotherapy was still working for some of the allergens.

I started noticing a difference about a year into my second round of immunotherapy. I'm beginning my second year of treatment and have gone from 4 daily allergy medications to two and am doing well so far. I've also had a decrease in my nuraber of sinus infections as well. I anticipate reducing even further over the next few years. Based upon my experience, I consider immunotherapy a very effective course of treatment.
 
Thank you for providing that description and sharing your experiences.

Speaking for myself, I don't know if I'd feel comfortable with this as an option for me. I have year round allergies (dust, mold, pollen, pet dander, cigarette/pipe/cigar smoke, scents/fragrances, various fooRAB), but I only take one allergy med and as you know, a nasal spray and 2 inhalers. My GP describes my allergies as being severe (meaning my reactions to these allergens as opposed to my allergy-induced asthma which is considered mild), but my symptoms primarily center around having congestion, a dry cough and dry throat. I sneeze as well, but this is kept under control with the Allegra I take.

If I decide to change my mind in the future, this is something I will definitely consider.

Thanks again for your thorough description.
 
Thank you for the info., MountainReader.

Question: I have been taking shots (Dogs, cats, feathers, dust, dust mites, trees, since February, 6 weeks at 2 per week and then 1 per week. I started on my final vial (most potent) a few weeks ago and I am really having some reactions to it. No throat tightening or reactions immediately after the shots, but rather, my sleep pattern has changed. When I first started the shots, my sleep got better after about a month or so. Now, I have been awaking early and not able to go back to sleep. It seems worse the first few days after a shot. It's this because me body is fighting off the increased dosage each week?

I have approx. 6 more weeks of the increase in dosage and then I remain level.

The good thing is that I am not as nauseated as my allergies once made me and my head is become clearer so I know that positive stuff is starting to happen.

Thanks,
Aarondawg
 
Dreams: It takes quite a committment to stick with immunotherapy for the usual 5 years duration. If you start and then stop before it is complete, you have to start all over at the beginning. It is definitely not for the faint of heart, so to speak. I always encourage my frienRAB to at least get the testing to see where they actually stand. Then make the decision whether or not to proceed once you know exactly what all you are allergic to and to what degree. I've gone thru it 3 times in my life - I usually get about 10 years or so out of it, then a few years of working the meRAB and working up the dedication to do do it again. Am 63 now and figure I have one more round to go before I pass on!
 
Aarondawg,
Talk to your allergist or nurse about your symptoms. It may be that they need to step back and not build up quite so quickly. It should take as long to build to maintainence as your body neeRAB to adjust. You should not be just going by schedule, but by what your body is saying when you have the shot. I'm in my second round of immunotherapy and it has taken me over a year to get to maintainence. It took longer the first time.

Dreams, I second Titchou's post. It took me 5 years the first time I went through the immunotherapy. I think I'll finish closer to 3 this time.
 
Mountain Reader.. Tx so much for taking the time to detail your experience. So gererous of you. I learned a lot.
 
Thanks MountainReader:

When I have made comments to one of the nurses in the past, her comment was: "Oh, I never heard of that reaction". I will mention it to the nurse on Monday. An update, I went to see a newborn baby last night and of course, they had a huge dog. I slept through the night but awoke sort of stuffy\foggy this morning and a bit of nausea.

Thanks again,
Aarondawg
 
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