The thing to remember with 4Kids is the limited funds. This means any show they produce or acquire needs to have limited funds spent on it. Acquiring any anime typically also means getting music rights, streaming rights, dubbing rights, etc. It can be a pretty hefty cost in the long run, though they are usually able to get around the music rights by producing their own music. That's also where the problem is when it comes to producing their own shows.
Frankly what 4Kids needs is a show that can appeal to kids and that they can have merchandising rights for. To me Web Ghosts PiPoPa would be a perfect fit on Toonzai for the early hours. The series is complete, it contains interesting monsters, and they could get a lot of merchandising sales by making dolls of PiPoPa, having various cell phone accessories of PiPoPa, etc.
In terms of original productions, I agree that they need their own series that has a good story and that they can have a lot of merchandising from. The question though is what type of series are there out there at this time? Warner typically has been the most successful at creating their own series (Ben 10, Fosters, Powerpuff Girls, Megas, etc.), but Disney (Phineas and Ferb) and Nick (Avatar) have also done well. Can 4Kids actually acquire a good storyteller though to create such a series? They'd have to get permission from FOX to do so, but frankly I think they could get such a series if they were to do an animated form of Eragon. Yes, the movie bombed, but an animated series would be able to follow the storyline more closely, and the storyline is interesting. Dragons, swords, magic, dwarves, elves, and monsters are just a few things that can attract kids interests that Eragon has in it, especially if they could end up animating all 4 books (I say 4 since there is still a 4th book to come). Yes, they might have to edit some of the story with Roran and Katrinna, but that is the only area that might have to be slightly adjusted for a children's animated story.