210,000 miles are far from fatal on a Jeep with a 4.0 engine. Will it make the trip? That answer depends on the maintenance the Jeep has had for those 210,000 miles. If the belts and hoses, cooling system, U-Joints [ a particularly weak link in Cherokees] are all up to snuff, you have covered over half the issues. It is so hard to find a shop that will evaluate a vehicle for a trip like this. The service writer gets paid selling you repairs. The mechanic gets paid by selling you repairs. It is hard to judge how objective these people really are. If the vehicle has been dependable without concern for local use, chances are it will be dependable for a trip as you describe, provided you are not entering a Cannon Ball Run. Get a good service done before you go.