It is possible and I've done it. I used panantukan, dumog and my smarts - not pretty, but I managed it without them laying a glove on me or having to seriously hurt them. (There were initially around 12 of them, but I only had to deal with 3 before the rest thought better of it.)
However it didn't look anything like the movies. Nor do I look anything like a movie star. Nor am I a geek.
In response to some of the above answers, yes it is possible, but you have to know what to do. It takes more brain than brawn. I'm not saying that I could take on 2 or more trained martial artists though. The guys I took on were just bullies with no training or much intelligence.