Make it a full-on All-American lampoon of the original:
Face: Owen Wilson
Murdoch: Will Ferrel
BA Barracus: Ice Cube
Hanibal, and this is the tough one: Kurt Russell I wouldn't disagree with, but maybe, if you can get him to stop taking himself so seriously, Russell Crowe (!?!?), Philip Seymore Hoffman would be great too, but you can say that about anything.