LOL ask me what I'd rather ride and I'll say the Ducati.
And you are wrong, the CBR 600 is water cooled and 410 lbs, the air cooled Ducati with a bigger motor is 369 lbs.
And if the nod goes to the air cooled twin, also look at Buell, they have some pretty sharp bikes in comparable price range that have bigger motor and lighter weight than the CBR 600.