Slinger,
Especially when you're folding Gromacs your CPU-temp can go up quite a bit.
For me this was a serious problem as I'm addicted to "silent computing" too, having a low airflow rig etc.
When you fold (and you should when you have your rig running anyway), keep an eye on those temps.
EDIT:
Motherboard Monitor is fine freeware to keep an eye on your CPU and HDs.
Regard the 65 degrees Celsius mark for your CPU as a border you shouldn't cross.
Han.
