Goosepimples: I am not on Spiro, but am on my third month of Yasmine which I guess has some Spiro in it. It has done wonders for my acne, but OH MY GOSH I have had some BAD cramping in my legs, feet, even my jaw when I yawn which has never happened to me, lol. Wonder if it's anything to be concerned about?? I was hiking last month and when I got to the top of the mountain, one of my calfs cramped up sooooo bad, and I've always hiked without the happening. Then, the other day my boyfriend was horsing around with me and tried to pull me into the cold shower and I braced myself with my legs so I didn't go in and BOTH my calves cramped at the same time!!! I couldn't freaking move, it hurt so bad and was so uncomfortable!