Sickle cell disease is caused by a?

  • Thread starter Thread starter nickjonasmichelle
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nickjonasmichelle

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a.
change in one DNA base.
b.
change in the size of a chromosome.
c.
change in two genes.
d.
change in the number of chromosomes in a cell.
 
A.

a normally hydrophillic glutamate amino acid into a hydrophobic Valine.
this causes the proteins outside centre to hide within the active site of another haemoglobin molecule and making them line up in a straight line. therefore causing inefficient oxygen binding.
 
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