The Edge has the same size engine, and can squeeze out more miles per gallon. As the other guy also said, the Edge has SYNC which is a really really cool system if you use your phone and/or iPod a lot.
Also, I think the grille of the Murano is a little overdone. They tried to make it really unique but it's just a little random so to speak. People say the Ford grilles are odd but they are just simple chrome bars with slick wraparound headlights... nothing overdone about that.