I would definitely imagine so. The products each by themselves, from my only slightly sensitive skin experiences are very irritating and drying. I would not trust even the most durable skin to withstand both in close proximity. Besides, the reactions I had to Nair on my legs was nothing short of a full-out rash w/ redness, swelling, and PAIN, so I pretty much would not get within ten yarRAB of nair for the face.
be careful. Proactiv hurts a little too if you get into the routine too thoroughly right away. Either way, give your skin time to adjust.