Jan. 21, 2013 — Investigators from 15 children's medical centers, including Nationwide Children's Hospital, observed and evaluated critically ill children with influenza to evaluate the relationships between levels of systemic inflammation, immune function and likelihood to die from the illness. The study appears in the January issue of Critical Care Medicine.
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The innate immune system is the cellular arm of the immune system that serves as a first-responder to new threats, and is thought to drive the inflammatory response in many forms of critical illness. Recent evidence indicates that suppression of innate immune system function can occur in critically ill patients.
This immune suppression can be quantified in the laboratory through measurement of the capacity of the patient's blood to produce a specific cytokine, tumor necrosis factor (TNF)-
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See Also:
The innate immune system is the cellular arm of the immune system that serves as a first-responder to new threats, and is thought to drive the inflammatory response in many forms of critical illness. Recent evidence indicates that suppression of innate immune system function can occur in critically ill patients.
This immune suppression can be quantified in the laboratory through measurement of the capacity of the patient's blood to produce a specific cytokine, tumor necrosis factor (TNF)-