say_sowhat
New member
I take Plaquenil for lupus, will cough medicine, dextromethorphan interfere with it?
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Lupus Cough Medicine Question
- Thread starter say_sowhat
- Start date
volleyballxoxox
New member
No, I don't think so, but ask your pharmacist to be sure.
Dex interferes with most antidepressants/antianxiety meds. Plaq doesn't play well with other antimalaria drugs like penicillamine (not the antibiotic) and Coartem, and the heart drug digoxin.
Dex interferes with most antidepressants/antianxiety meds. Plaq doesn't play well with other antimalaria drugs like penicillamine (not the antibiotic) and Coartem, and the heart drug digoxin.
Yes, both affect serotonin and in rare cases can lead to serotonin syndrome. You'll have to ask a doctor if they're safe together in some individual cases.
I found this suggestion: "MONITOR CLOSELY: Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1 receptor agonists, ergot alkaloids, lithium, St. John's wort, phenylpiperidine opioids, dextromethorphan, and tryptophan may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucinations, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea."
I found this suggestion: "MONITOR CLOSELY: Concomitant use of agents with serotonergic activity such as serotonin reuptake inhibitors, monoamine oxidase inhibitors, tricyclic antidepressants, 5-HT1 receptor agonists, ergot alkaloids, lithium, St. John's wort, phenylpiperidine opioids, dextromethorphan, and tryptophan may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucinations, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea."