IS 250
Price Range: $30,855 - $34,785
IS 350
Price Range: $36,305 - $36,605
Cost
The Lexus IS 250 will save you money at the pump compared to the Lexus IS 350. As far as gas mileage, the IS 250 bests the IS 350. The IS 250 is significantly less expensive than the Lexus IS 350 in terms of MSRP. When it comes to out-the-door price, the Lexus IS 250 costs significantly less than the Lexus IS 350.
Utility
The Lexus IS 250 and the Lexus IS 350 can accommodate the same number of passengers.
Convenience
The IS 350's fuel tank will need to be replenished more often than the unit in the Lexus IS 250.
Dimensions
The Lexus IS 350 is a tad heavier than the Lexus IS 250.
Performance
With that kind of horsepower, the IS 350 is a veritable speedster.
Drivetrain
The Lexus IS 350's engine is substantially more massive than the IS 250's. Remember that more sizeable engines may use more gasoline than smaller ones. The Lexus IS 250 could learn a lesson or two from the Lexus IS 350 when it comes to pickup. Torque is the force that lets you accelerate quickly, and in this respect, the Lexus IS 350 is quite a bit more powerful than the Lexus IS 250.
Overview
The Lexus IS 350 and the IS 250 have the same basic after-sale protection.