P
PSawyer
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its substrate, GDP. Explain why.? 2. The following diagram shows the active site of an enzyme (G-Protein) with a molecule of GDP in it. Notice the exposed side chains in the enzyme’s active site.
Imagine that you can induce mutations (change the amino acids) in the binding pocket of the G-protein shown above, and hence change the side chains that line the active site. If Asp is mutated to a Proline, the result is a G protein that cannot bind its substrate, GDP. Explain why. Include in your discussion how all levels of protein structure may be changed by this mutation.
Imagine that you can induce mutations (change the amino acids) in the binding pocket of the G-protein shown above, and hence change the side chains that line the active site. If Asp is mutated to a Proline, the result is a G protein that cannot bind its substrate, GDP. Explain why. Include in your discussion how all levels of protein structure may be changed by this mutation.