How did they become 'lost', and where were they?
If somehow an astronaut on the ISS were to float away or be thrown away due to some calamity (an explosion, perhaps?), he/she would continue to float in the same direction until gravity or friction pulled him/her back.
In the case of the ISS, unless the astronaut was given a huge component of speed (something that would easily be enough to kill them) in the right direction, he/she would eventually encounter enough friction from air to slow them enough that they would reenter the earth's atmosphere.