Identify if each of the following statements about Chomatin and genes is true or false.?

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Curt B

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Chromatin is brought to the interchromosomal space where transcription factors and splicing factors are present.
Chromosomal domains generally contain splicing factors.
Portions of DNA with a higher gene density are more likely to be involved in late replication.
Gene density refers to how tightly packed the chromosome is.
 
1) Chromatin is brought to the interchromosomal space where transcription factors and splicing factors are present.
FALSE - Chromatine is one of the names of the DNA molecule - when the molecule is "relaxed" to be precise. DNA never leaves the nucleus.

2)Chromosomal domains generally contain splicing factors.
This question is unclear: a "factor" is generally a protein, so a DNA domain cannot "contain" a protein. It may contain regions recognized by those factors or it may code for those factors, though

3) Portions of DNA with a higher gene density are more likely to be involved in late replication.
This is what the general knowledge says, but there is no real evidence for this to be true. In fact, still to this point it is not clear what defines an origin of replication in a higher eukaryotic cell (I know, as I worked on DNA replication for several years)

4) Gene density refers to how tightly packed the chromosome is.
TRUE
 
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