When a cat acts out of the ordinary it is usually a sign to you that something could be wrong. So a trip to the vet is likely your best bet. But to give you some ideas of what could be wrong with her I'll tell you what this behavior could mean(I was a vet tech before I started law school, plus I've had several cats so you get to know signs of certain common ailments). First of all if she is unneutered she may be in heat. A cat in heat can act differently then you're use to. However, if you've had her a while and she's never done this then that's probably not the case. Secondly, she could have a urinary tract infection. I had a cat who got these quite often and she would whine and meow a lot like she was in pain. If you've noticed urine that has a pinkish tint or a stronger odor than usually this might be the problem. Other possibilities is that she might have hurt her leg (could explain the slow moving). There are numerous things it could be and the best bet is to go to the Vet and have him/her check her out to make sure she's ok. If she's not eating, then you definitely need to take her to the Vet, ASAP. When a cat stops eating it's a sign of sickness, their way of telling you I don't feel good.
If you wanted to see if she's in pain anywhere you could gently palpate her (like the vet does while examining the cat), I'd only try this is she's agreeable to you poking around on her. It's always good to know where the cat hurts so when the Vet asks you can give him/her all the information you know.
Good luck and I hope your cat is ok.
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