We are renting a pet friendly house in Fla. and bringing my italian greyhound. The drive is about 13 hours each way. He dosnt have many opportunities to go in the car so he kind of gets scared. Some people suggested benadryl or dramine. I don't have a good relationship with the vet so I don't think he would give me a prescription for something. I might also mention that we don't crate him. He's a puppy mill dog and kind of freaks out. He's very skiddish. He's 4 and had all his puppy shots but none since. He has seizures and some of them are stress related. Boarding him is not an option because of this. I have no one at home to watch him as we are all going on this vacation. I would really appreciate some suggestions and nothing about him not having vaccinations. Sorry about all the bad spelling.