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So I'm trying to take a practice test since I have the real one coming up, but I could not find the answer key to this, I was wondering if anyone could chip in on this? - Thanks
1.Which of the following statements about spontaneity is correct?
1.All reactions with ? GEN < 0 will be spontaneous.
2.All reactions which have ? H < 0 will be spontaneous.
3.All reactions for which ? G is not equal to zero will be spontaneous.
4.All reactions for which have ? G < 0 will be spontaneous.
5.All reactions for which have ? S < 0 will be spontaneous.
2.For the reaction
A º B + C
? GEN = -2.00 kcal/mol. What is ? G at 25EC if the concentration of each of the three reacting species is 1 M? (NOTE: 2.3 X 1.987 X 298 = 1.36; log 1.36 = 0.13)
1.-3.36 kcal/mol
2.-2.13 kcal/mol
3.-2.00 kcal/mol
4.+2.00 kcal/mol
5.+2.13 kcal/mol
3.An important characteristic of living systems is that
1.They are always at equilibrium.
2.They are perturbed from equilibrium only when experiencing stress.
3.They are never at equilibrium.
4.They are at equilibrium only when metabolic activity is low.
5.The laws of thermodynamics do not apply.
4.All the following statements about ATP are correct EXCEPT
1.ATP has two phosphoanhydride bonds.
2.ATP has one phosphate ester bond.
3.ATP has a ? GEN of hydrolysis.
4.ATP is usually complexed with Mg2+.
5.ATP has three high energy bonds.
5.All the following compounds are high energy compounds EXCEPT
1.acetyl coenzyme A
2.creatine phosphate
3.glucose-6-phosphate
4.phosphoenolpyruvate
5.ADP
6.The large negative value for ? GEN of hydrolysis of phosphoenolpyruvate is primarily due to
1.hydrolysis of a phosphoanhydride bond
2.hydrolysis of a phosphate ester bond
3.the combined effect of hydrolysis and subsequent conversion of the keto form of pyruvate to the enol form
4.the combined effect of hydrolysis and subsequent conversion of the enol form of pyruvate to the keto form
5.hydrolysis of a thiol ester bond
7.For glucokinase, Km = 10 mM, while for hexokinase, Km < 0.1 mM. These data are consistent with which of the following statements?
1.Hexokinase acts only at low blood glucose levels.
2.Glucokinase acts only at high blood glucose levels.
3.Glucokinase plays a major role in glucose metabolism only at low levels of blood glucose.
4.Hexokinase acts only at high levels of blood glucose.
5.Glucokinase can effectively remove enzyme-bound glucose from hexokinase.
8.The enzyme catalyzing the reaction that commits glucose to glycolysis is
1.hexokinase.
2.phosphoglucoisomerase.
3.phosphofructokinase-1.
4.aldolase.
5.phosphotriose isomerase.
9.All of the following are true of phosphofructokinase-1 EXCEPT?
1.Phosphofructokinase-1 is an allosteric enzyme.
2.Citrate increases the activity of phosphofructokinase-1.
3.AMP increases the activity of phosphofructokinase-1.
4.Phosphofructokinase-1 is subject to regulation by covalent modification.
5.Glucagon indirectly lowers the activity of phosphofructokinase-1.
10.Substrate-level phosphorylation occurs in glycolysis in the reaction catalyzed by
1.hexokinase
2.phosphofructokinase-1
3.phosphoglycerate kinase
4.glyceraldehyde-3-phosphate dehydrogenase
5.aldolase
11.Binding of glucagon to its receptor leads to adenylate cyclase-catalyzed synthesis of c-AMP, which activates protein kinase A. This leads to:
1.Dephosphorylation of PFK-2/F-2,6-bisphosphatase, hydrolysis of F-2,6-BP, and decrease in glycolytic activity
2.Dephosphorylation of PFK-2/F-2,6-bisphosphatase, hydrolysis of F-2,6-BP, and increase in glycolytic activity
3.Phosphorylation of PFK-2/F-2,6-bisphosphatase, synthesis of F-2,6-BP, and decrease in glycolytic activity
4.Phosphorylatlon of PFK-2/F-2,6-bisphosphatase, hydrolysis of F-2,6-BP, and decrease in glycolytic activity
5.Phosphorylatlon of PFK-2/F-2,6-bisphosphatase, hydrolysis of F-2,6-BP, and increase in glycolytic activity
12.In anaerobic glycolysis from glucose to lactate, how many net moles of ATP and how many net moles of NADH are produced for each mole of glucose?
ATP NADH
A) 0 2
B) 2 0
C) 2 2
D) 4 0
E) 4 2
13.All of the following statements about the pyruvate dehydrogenase complex are correct EXCEPT?
1.Pyruvate dehydrogenase is inhibited by acetyl CoA and NADH.
2.Pyruvate dehydrogenase is activated by dephosphorylation and inactivated by phosphorylation.
3.The reaction catalyzed by the pyruvate dehydrogenase complex requires TPP, NAD+, FAD and 2,3 bisphosphoglycerate.
4.The products of the reaction catalyzed by the pyruvate dehydrogenase complex are acetyl CoA, CO2, and NADH.
5.Genetic pyruvate dehydrogenase deficiency may be treated with dichloroacetate.
14.Oxidation of one molecule of pyruvate by pyruvate dehydrogenase and one turn of the TCA cycle results in net formation of how many molecules of each of the following?
GTP
1.Which of the following statements about spontaneity is correct?
1.All reactions with ? GEN < 0 will be spontaneous.
2.All reactions which have ? H < 0 will be spontaneous.
3.All reactions for which ? G is not equal to zero will be spontaneous.
4.All reactions for which have ? G < 0 will be spontaneous.
5.All reactions for which have ? S < 0 will be spontaneous.
2.For the reaction
A º B + C
? GEN = -2.00 kcal/mol. What is ? G at 25EC if the concentration of each of the three reacting species is 1 M? (NOTE: 2.3 X 1.987 X 298 = 1.36; log 1.36 = 0.13)
1.-3.36 kcal/mol
2.-2.13 kcal/mol
3.-2.00 kcal/mol
4.+2.00 kcal/mol
5.+2.13 kcal/mol
3.An important characteristic of living systems is that
1.They are always at equilibrium.
2.They are perturbed from equilibrium only when experiencing stress.
3.They are never at equilibrium.
4.They are at equilibrium only when metabolic activity is low.
5.The laws of thermodynamics do not apply.
4.All the following statements about ATP are correct EXCEPT
1.ATP has two phosphoanhydride bonds.
2.ATP has one phosphate ester bond.
3.ATP has a ? GEN of hydrolysis.
4.ATP is usually complexed with Mg2+.
5.ATP has three high energy bonds.
5.All the following compounds are high energy compounds EXCEPT
1.acetyl coenzyme A
2.creatine phosphate
3.glucose-6-phosphate
4.phosphoenolpyruvate
5.ADP
6.The large negative value for ? GEN of hydrolysis of phosphoenolpyruvate is primarily due to
1.hydrolysis of a phosphoanhydride bond
2.hydrolysis of a phosphate ester bond
3.the combined effect of hydrolysis and subsequent conversion of the keto form of pyruvate to the enol form
4.the combined effect of hydrolysis and subsequent conversion of the enol form of pyruvate to the keto form
5.hydrolysis of a thiol ester bond
7.For glucokinase, Km = 10 mM, while for hexokinase, Km < 0.1 mM. These data are consistent with which of the following statements?
1.Hexokinase acts only at low blood glucose levels.
2.Glucokinase acts only at high blood glucose levels.
3.Glucokinase plays a major role in glucose metabolism only at low levels of blood glucose.
4.Hexokinase acts only at high levels of blood glucose.
5.Glucokinase can effectively remove enzyme-bound glucose from hexokinase.
8.The enzyme catalyzing the reaction that commits glucose to glycolysis is
1.hexokinase.
2.phosphoglucoisomerase.
3.phosphofructokinase-1.
4.aldolase.
5.phosphotriose isomerase.
9.All of the following are true of phosphofructokinase-1 EXCEPT?
1.Phosphofructokinase-1 is an allosteric enzyme.
2.Citrate increases the activity of phosphofructokinase-1.
3.AMP increases the activity of phosphofructokinase-1.
4.Phosphofructokinase-1 is subject to regulation by covalent modification.
5.Glucagon indirectly lowers the activity of phosphofructokinase-1.
10.Substrate-level phosphorylation occurs in glycolysis in the reaction catalyzed by
1.hexokinase
2.phosphofructokinase-1
3.phosphoglycerate kinase
4.glyceraldehyde-3-phosphate dehydrogenase
5.aldolase
11.Binding of glucagon to its receptor leads to adenylate cyclase-catalyzed synthesis of c-AMP, which activates protein kinase A. This leads to:
1.Dephosphorylation of PFK-2/F-2,6-bisphosphatase, hydrolysis of F-2,6-BP, and decrease in glycolytic activity
2.Dephosphorylation of PFK-2/F-2,6-bisphosphatase, hydrolysis of F-2,6-BP, and increase in glycolytic activity
3.Phosphorylation of PFK-2/F-2,6-bisphosphatase, synthesis of F-2,6-BP, and decrease in glycolytic activity
4.Phosphorylatlon of PFK-2/F-2,6-bisphosphatase, hydrolysis of F-2,6-BP, and decrease in glycolytic activity
5.Phosphorylatlon of PFK-2/F-2,6-bisphosphatase, hydrolysis of F-2,6-BP, and increase in glycolytic activity
12.In anaerobic glycolysis from glucose to lactate, how many net moles of ATP and how many net moles of NADH are produced for each mole of glucose?
ATP NADH
A) 0 2
B) 2 0
C) 2 2
D) 4 0
E) 4 2
13.All of the following statements about the pyruvate dehydrogenase complex are correct EXCEPT?
1.Pyruvate dehydrogenase is inhibited by acetyl CoA and NADH.
2.Pyruvate dehydrogenase is activated by dephosphorylation and inactivated by phosphorylation.
3.The reaction catalyzed by the pyruvate dehydrogenase complex requires TPP, NAD+, FAD and 2,3 bisphosphoglycerate.
4.The products of the reaction catalyzed by the pyruvate dehydrogenase complex are acetyl CoA, CO2, and NADH.
5.Genetic pyruvate dehydrogenase deficiency may be treated with dichloroacetate.
14.Oxidation of one molecule of pyruvate by pyruvate dehydrogenase and one turn of the TCA cycle results in net formation of how many molecules of each of the following?
GTP