Genetic mutation linked with typical form of migraine headache

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May 1, 2013 — A research team led by a Howard Hughes Medical Institute investigator at the University of California, San Francisco has identified a genetic mutation that is strongly associated with a typical form of migraine.

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In a paper published on May 1 in Science Translational Medicine, the team linked the mutation with evidence of migraine in humans, in a mouse model of migraine and in cell culture in the laboratory.
The mutation is in the gene known as casein kinase I delta (CKIdelta).

“This is the first gene in which mutations have been shown to cause a very typical form of migraine,” said senior investigator Louis J. Ptá
 
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