Mac OS X only: Free menu bar application EverSave automatically saves your open documents on a regular interval so that you'll never again lose progress to a crashed application.
Once installed, open up the EverSave preferences to determine what applications you'd like it to work with. EverSave can save changes on all applications or only listed apps, it can save every time you switch applications or based on a timed interval, and in general it's very configurable. EverSave appears to work with most applications, including Microsoft Office 2004 and 2008. The simple utility seems like a tool that could save a lot of wasted time if properly configured with the way you work. EverSave is a free download, Mac OS X only.
EverSave [via Cool OSX Apps]