It's really just like any S60 device without a keyboard. I have exchange server and I'm testing Roadsync right now since mail for exchange does not support N-series phones. I'm on the fence about Roadsync because they don't have email notification sign on the phone, only new email sound comes on, therefore if you didn't hear the sound you would not know if you got email unless you went into messages.
Other than that, there's not much else I can share with you. Have you used S60 for emails?