Ryber and Dwinget both have got good points (again). Also, if you have Mobile DB, you actually DO NOT have to bring it into Access. It will IMPORT a CSV file and turn it into a Mobile DB on the spot, and you can move the columns around if "names" aren't on the left (1st).
I learned that only because I'm a complete BOOB when it comes to Access -- can't figure that thing out AT ALL. Think I'll launch something from Cape Kennedy before I ever get a database looking good in it . . . I need to find a tutorial!!
Anyway, back on focus: NATIVE excel, and for laughs try the CSV thing and see how you like it -