flies! How can we STOP the LIES? Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception p597
Reactive electrophiles are noxious chemicals, such as acrolein in cigarette smoke, and are detected by the ion channel TRPA1 in humans. Here it is shown that TRPA1 channels sense these chemicals in the gustatory chemosensory neurons of fruitflies and mosquitoes, too. Further findings show that, unlike with other chemical senses such as smell or taste, the detection of reactive electrophiles relies on an ancient sensor that has been conserved in molecular detail through some 500 million years of evolution.
Kyeongjin Kang, Stefan R. Pulver, Vincent C. Panzano, Elaine C. Chang, Leslie C. Griffith, Douglas L. Theobald & Paul A. Garrity
Nature Volume 464 Number 7288
Reactive electrophiles are noxious chemicals, such as acrolein in cigarette smoke, and are detected by the ion channel TRPA1 in humans. Here it is shown that TRPA1 channels sense these chemicals in the gustatory chemosensory neurons of fruitflies and mosquitoes, too. Further findings show that, unlike with other chemical senses such as smell or taste, the detection of reactive electrophiles relies on an ancient sensor that has been conserved in molecular detail through some 500 million years of evolution.
Kyeongjin Kang, Stefan R. Pulver, Vincent C. Panzano, Elaine C. Chang, Leslie C. Griffith, Douglas L. Theobald & Paul A. Garrity
Nature Volume 464 Number 7288