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If you are careful about taking your lenses off in areas of blowing dust you will still not have to have the sensor cleaned very often, I would still say get eh D3X and keep the D300 as a backup you will do great with that
Here is the benchmark comparison on sensor RAW data from DXO for the D300, D3 and Canon 1Ds Mark III they do not have the D3X on here yet but it will have better marks than the D3
http://www.dxomark.com/index.php/eng/Image-Quality-Database/Compare-cameras/(appareil1)/262%7C0/(appareil2)/209%7C0/(appareil3)/192%7C0/(onglet)/0/(brand)/Nikon/(brand2)/Nikon/(brand3)/Canon
Canon and Nikon both make good cameras and lenses so alot of it is personal preference but remember the controls on the D3X will be very similar to your D300 so there will not be a large learning curve
Here is the benchmark comparison on sensor RAW data from DXO for the D300, D3 and Canon 1Ds Mark III they do not have the D3X on here yet but it will have better marks than the D3
http://www.dxomark.com/index.php/eng/Image-Quality-Database/Compare-cameras/(appareil1)/262%7C0/(appareil2)/209%7C0/(appareil3)/192%7C0/(onglet)/0/(brand)/Nikon/(brand2)/Nikon/(brand3)/Canon
Canon and Nikon both make good cameras and lenses so alot of it is personal preference but remember the controls on the D3X will be very similar to your D300 so there will not be a large learning curve