May 5, 2013 — Peptide receptor radionuclide therapy (PRRT) with radiolabeled somatostatin analogs, an established treatment for cancer patients, could offer a novel therapeutic approach to decrease levels of inflammation in the atherosclerotic plaques of patients with cardiovascular disease (CVD), reported an abstract¹ study at the International Conference on Nuclear Cardiology and Cardiac CT, May 5 to 8 in Berlin, Germany.
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"Our results should act as a stimulus for further exploration of radionuclide based interventions in atherosclerosis. Ultimately such therapies might be used to lower the degree of inflammation in atherosclerosis which has the potential to reduce the occurrence of heart attacks," said Imke Schatka, the first author of the study from the Department of Nuclear Medicine at Hannover Medical School, Germany.
PRRT is a technique currently used to treat patients with metastatic neuroendocrine tumours (NETS), a diverse group of malignancies deriving from the neuroendocrine cell system (the most frequent locations being pancreas, small intestine and lung).
The discovery of over expression of somatostatin receptors (SSTR) on NET tumours first opened the way for development of radiolabelled somatostatin analogs to image tumours during PET/CT scans. DOTATATE is a somatostatin receptor (SSTR) ligand targeting SSTR-2, a receptor known to be expressed on 70% of NET tumours. Once tumours have been visualized, it is possible to target therapy by attaching the beta-emitter ¹
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"Our results should act as a stimulus for further exploration of radionuclide based interventions in atherosclerosis. Ultimately such therapies might be used to lower the degree of inflammation in atherosclerosis which has the potential to reduce the occurrence of heart attacks," said Imke Schatka, the first author of the study from the Department of Nuclear Medicine at Hannover Medical School, Germany.
PRRT is a technique currently used to treat patients with metastatic neuroendocrine tumours (NETS), a diverse group of malignancies deriving from the neuroendocrine cell system (the most frequent locations being pancreas, small intestine and lung).
The discovery of over expression of somatostatin receptors (SSTR) on NET tumours first opened the way for development of radiolabelled somatostatin analogs to image tumours during PET/CT scans. DOTATATE is a somatostatin receptor (SSTR) ligand targeting SSTR-2, a receptor known to be expressed on 70% of NET tumours. Once tumours have been visualized, it is possible to target therapy by attaching the beta-emitter ¹