Can propane bottles be unscrewed from camping stoves?

[Andy]

First time camper. I bought a camping stove and I can buy a propane bottle that I can screw to the adaptor on the stove.

Because the adaptor with the bottle stick out, I wanted to find out if it is safe to unscrew the bottle with propane in it from the stove prior to travel. I wanted to make sure I didn't do something to result in a leak.

Thanks