Can not using the "safely remove drive" kill a flash drive?

My sister said she took her USB out of a school computer without doing the "safely remove hardware" thing and now when she puts it in at home nothing happens. The light doesn't come on and it doesn't show up on the drive list either. Could not "safely" taking it out have killed it? Can it be fixed?
We have tried it on both a PC and a Mac.
So there's absolutely no way to get the files off of it?
 
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