Splenda is a favorite of many low-carb fans because it cuts calories in processed foods. But the calorie savings can be deceiving.. If you make a muffin with Splenda instead of sugar you can reduce the calories by about 20% . You can also save an equivalent amount of calories by alternatively reducing the fat in a recipe. So yes, you can realize some calorie savings in processed foods by cutting carbs or cutting fat. However, you can’t change the fact that processed foods are very calorie dense