No, why would you even consider this??? You should never on purpose breed mixes, or anything that would become a mix. The ONLY reason to breed dogs is if you have experience breeding, your dogs are show quality, not to mention full-blooded, and they have papers.
Anything can happen during pregnancy to dogs, including death, (to mom or pups) c-section, hernias, and it decreased the life of your dog every time she mates. Reputable breeders are lucky to break even when selling pups, because so much time and money are spent on them. Vet visits for the mom are eccential, and you have to worm and vet the puppies.
If your seriously wanting to breed dogs, read up and find out more info. Then talk to your vet, and get 2 full blooded dogs, from separate litters.