Can chemistry between people be hindered by insecurities?

Like, say one person is a really insecure person, codependent and full of self doubt. Reads and overthinks and analyzes everything their partner says. Could this kind of thing hinder any possible chemistry they might have romantically with others? Like if this person got better and got help, become more confident and gained self esteem, maybe it would make them interact better a produce better chemistry?

My ex felt we didn't have good chemistry. But the thing was, I was ALWAYS anaylizing the things he said, getting upset and taking seriously any small jokes. And I felt there was potential there but I was just so so insecure...getting all clingy and needy. And depressed, too. I find relationships I have with friends are different compared to when I've not been depressed.

I'm starting therapy soon and I just wonder if the ex and I, how things would click if I were improved and on my well to a healthier state of mind.
I feel like I could meet the man of my dreams and the chemistry would be off because I wouldn't be myself, you know? All depressed and codependent and stuff...
Yeah he would say often that I don't "get him" but that's because I didn't pay attention, I was so wrapped up in myself and my own insecurities (and I wasn't insecure just because of him, I wasl ike that before him)
 
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