I have tried both name brand and generic. For many medications, I would tell you the generic is as good as the name brand, however, for me that was not the case with Accutane.
I took Accutane a # of years ago (probably around 8-10 years ago). I loved it. I was one of those people that did not have a single bad side effect from it. My skin also stayed clear for quite some time after going off of it and I really didn't have to go on any other medications for a long while.
However, over time, I started seeing my skin act up again. I tried some of the other medications but about a year ago I asked to go on Accutane again. This time around I was given the generic version called Sotret. It did clear up my skin, although I think it took a lot longer to see results. With the Sotret, while I again did not really have any bad side effects, I did experience severe dry lips (to the point where they were bleeding) after being on it the first month. That was the case until I was finished with the cycle. I pretty much carried Carmex with me 24-7 and was constantly putting it on to no avail. Also, I feel like my skin did not really stay clear for very long after going off of it.
Now, part of that could be due to the fact that I don't think acne medications tend to be as effective the 2nd time around, even years later. The doctor even told me as much. However, if I was to be given the choice again, I would definitely spend the little extra and go w/the brand name. Also, with the Sotret, while it was the same total dosage as when I was on the Accutane, my prescription was written for 2 pills a day. I much preferred taking it the once with the Accutane and getting it out of the way, Much less opportunity to forget taking that second pill.
Anyway, hope this helps!