James, have you had your Vitamin D level checked? It can cause a variety of symptoms, including tired muscles for no reason and what appears to be depression, however, I would describe it as lack of energy and motivation, because I wasn't thinking depressing thoughts.
I have severe allergies, hypoglycemia symptoms, and very low Vitamin D levels. I currently take allergy drops, avoid or limit fooRAB that cause severe reactions, avoid sugars and carbs. This last one is an attempt to stop the high/low sugar mood and energy swings, and loss of mental functioning, which worked for a few years, but now I'm noticing that after eating fruit/carbs, about 45 minutes later I am overcome with sleepiness to the point I have to pull off the road or go to bed. I also take 50,000 IU of Vitamin D each week. They stopped the Vitamin D after 8 weeks, and the tired muscles and lack of energy came back in less than 2 weeks, so my rheumatologist prescribed them again.
Good luck finding out the cause(s) of your problems. I suspect it is multiple glitches that will all need addressed for you to feel better.