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1. Unhook the battery as previously suggested. 2. Use a filter wrench to remove the filter, you could be turning it backwards. Lefty loosey, righty tighty - tougher to figure out upside down. 3. If all else fails, jam a screw driver through it to turn it 4. If this fails, use a chisel tip punch...

Not good. Don't even ask about mileage if you're driving an F-450. There are too many unknowns with your question: gear ratio, standard/automatic, year, what you are towing/hauling, 2x4/4x4. Say city 8-10mpg, highway 10-15mpg.