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Sadly, the most accurate answer is "we just don't know." Wiped out isn't the correct wording however, think more "changed and moved on and away." Every civilization falls. There are many who attribute the decline of the IVC to climate change (see the wiki link below) and this wouldn't have...

Sylvia Plath suffered from severe depression. She had several breakdowns, underwent shock treatment, but sometimes there is nothing to be done. It is worth nothing that her son very recently committed suicide as well. Earlier this year actually. There is some evidence that depression is inherited.